SUNY-ESF FCH540:

Chemistry of Carbohydrates and Polysaccharides I: Structure, Analysis and Reactions

Schedule Fall 2003 - Tentative

Text:  J. F. Robyt "Carbohydrate Chemistry: ", (1998) and readings on reserve
NOTE: Lectures and online assignments are accessible only to SUNY-ESF/Syracuse University Students using machines in the syr.edu (128.230.nn.nnn) and esf.edu (149.119.nn.nnn) domains


In the table below the lilac color designates  completed lectures

 
 


 

FCH540: Course Roadmap 

This page is subject to change, check back often
No.
Date
Topic
Reading
Assign
1
W 8/27
"Introductory Lecture"
1-7
 Read Critical Reading of a Scientific Paper
Send a message to the FCH540 group.  Tell the other members about yourself and what you hope to get from this class
2
Th 8/28
Carbohydrate Structure
Furans
 8-33
  Carbohydr Chem (U. Strathclyde)
       look at the introduction section 
Monosaccharide browser-leeds Univ -Dr. Maber
    This site lets you select sugars and view them one by one
3
Tu 9/2
    "Nomenclature" 
 34-47,  365-381, 
   a) Nomenclature 
  b)  prob. set 1
       answers
 4
Th 9/4
 "Nomenclature II" 
 
 
5
Th 9/11
"Overview of Structure Determination"
 345-362, 
 Polysaccharide Analysis
6
F 9/12
 Methods of Linkage Determination
 Carbohydr.
Res. 42:95-105 (1975)
1. Complete the Problem Sheet, 
2. Be able to discuss the paper 
7
Th 9/18
Chemical Routes to Configuration Determination

Other substituents
 
 
8
Tu 9/23
Case study in chemical sequence analysis
 
 
9
Th 9/25

  Carbohydrate NMR - introduction
A  useful review of NMR Basics
 Use SUGABASE to find and report the chemical shifts (C and H ) for a disaccharide fragment 
Question:  How many entries contain L-rhamnose? send you answer to the e-group
10
Tu 9/30
 Multidimensional Carbohydrate NMR:  COSY, TOCSY, HMQC, HMBC
 A second NMR TUTORIAL
 NMR homework Prob
11
Th 10/2
 Continue NMR- NOESY/ROESY
 read 
  1.  Chapter 9 - section on NOE in the 2nd tutorial whose link is above.
  2. New Tricks with Isotopically Enriched Oligosaccharides - S.W.  Homans, Biochem. Soc Trans (1998) 26:551-560  (available online)
 NOE 
12
 Tu 10/14
 Introduction to Molecular Modeling of Carbohydrates
 NIH Guide to Molecular Modeling
Macromolecular Simulation
 
13
 Th 10/9
 Discussion of Molecular Dynamics
 Polysaccharide Modeling
 
14
Tu 10/14
 
 
 
15
Th 10/16
Mass Spectroscopy
 Introduction to  Spectroscopy
Ionization Methods
 Oral Exam Schedule
16
Tu 10/21
Mass Spectroscopy
 MALDI  TOF tutorial
 
17
Th 10/23
Cellulose, sources, characterization
 
 The rest of Problem Set I, due 11/5
18
 Tu 10/28
  Reactions of cellulose
 
 
19
Th 10/30
 
 
 
20
 Tu 11/4
 
 
 
21
 Th 11/6
 reactions of carbohydrates
 
 Chapter 4 sect 1-4
22
Tu 11/11
Glycosaminoglycans, Proteoglycans
Glycoproteins 
 
Hyaluronic acid links 
23
Th 11/13
 
 
 Heparin / Prob set 2 due
24
  Tu 11/18
 
 
 
25
  Th 11/20
Student Presentations 
 
 
26
Tu 11/25 
Student Presentations
GlycoInformatics
 
 

M  12/08
Final examination 2:45 - 4:45 pm*

The Final Date of 12/08/2003 was posted on this page on August 27th, 2003 please do not request permission to take the exam at another time, the ansTuer Tuill be NO.

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Page last modified Dec 4., 2003
Comments and corrections to cellulose@esf.edu
Copyright 2003 by William T. Winter