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Ivan Gitsov Ivanov

Ivan Gitsov Ivanov
Chair, Associate Professor and Director, Michael M. Szwarc Polymer Research Institute

217 Jahn Lab
1 Forestry Dr.
Syracuse, New York 13210

Phone: (315) 470-6851

Email: igivanov@syr.edu

Education

Employment

  • 1985-1986, Research Associate, Institute of Polymers, BAS, Sofia;
  • 1987-1993, Research Associate, Senior Research Associate, R&D Institute for Special Chemicals, Sofia;
  • 1990-1996, Visiting Scientist, Research Associate and Manager of the Polymer Characterization Facility, Cornell University and Cornell Center for Materials Research;
  • 1996-2000, Visiting Assistant Professor, Cornell University.

Polymer Research Institute

Current Organic Chemistry, US Regional Editor

http://benthamscience.com/journal/index.php?journalID=coc

Honors

The research efforts in our group are focused on the design, synthesis and evaluation of novel polymers and copolymers with unique architecture, composition and properties that can be used for advanced applications. The synthetic projects involve extensive use of various methods for organic functional group (trans)formation, polycondensation techniques and multiple procedures for controlled or "living" chain-growth polymerization. State-of-the-art methods for isolation, identification and characterization of the macromolecules formed are used including size-exclusion chromatography with multiple detection, FT-IR, UV-Vis, Fluorescence and NMR spectroscopies, mass spectrometry and microscopy. The biological activity and biocompatibility of selected materials are evaluated in collaboration with other research groups and laboratories in USA and Europe. The combination of these methods places our research at the interfaces of organic chemistry, polymer science, biotechnology and molecular medicine (see a recent news reports on our activities in this area  https://nccnews.expressions.syr.edu/health/suny-esf-researchers-seek-revolutionary-cancer-treatment/ and http://www.esf.edu/communications/view.asp?newsID=3604).

Our efforts are almost equally divided between the creation of novel macromolecular architectures (linear-dendritic copolymers and hydrogels, star-graft and comb-graft copolymers) and the evaluation of materials formed for novel biomedical applications (polymeric prodrugs, systems for covalent or passive drug binding and sustained delivery) and for new biotechnological applications (formation of unique semi-artificial enzymes through site-specific nano-contacts and no chemical / genetic modification of the proteins).

A leading motif throughout our research is the development and use of “green” and sustainable chemistry practices.

image of Cross-polarized optical micro-photography of a supermolecule formed in water by self-assembly of amphiphilic linear-dendritic copolymers

Cross-polarized optical micro-photography of a supramolecular crystal, formed in water by self-assembly of amphiphilic linear-dendritic copolymers.

Supramolecular modification of the enzyme laccase by  [G-2]-PEO13000-[G-3] in Aqueous Media.  For more details see: Polymer-Assisted Biocatalysis: Unprecedented Enzymatic Oxidation of Fullerene in Aqueous Medium; J. Polym. Sci., Part A: Polym. Chem. 50(1), 119-126 (2012); I. Gitsov, A. Simonyan, L. Wang, A. Krastanov, S.W. Tanenbaum, D. Kiemle

If you want more information about the graduate program, please follow this link to a brief form


Current Graduate Advisees

Current Graduate Advisees

Xin LiuXin Liu
xliu70@syr.edu

  • Degree Sought: PHD
  • Graduate Advisor(s): Gitsov
  • Area of Study: Polymer Chemistry

Dieter ScheibelDieter Scheibel
dmscheib@syr.edu

  • Degree Sought: PHD
  • Graduate Advisor(s): Gitsov
  • Area of Study: Polymer Chemistry

Novel Macromolecular Architectures

Novel Polymers

Synthesis and Characterization of Novel Amphiphilic Super-H Copolymers with Linear–Dendritic Architecture J. Polym. Sci., Part A: Polym. Chem. 53, 178-182 (2015) I. Gitsov, I.V. Berlinova, N.G. Vladimirov 

"Click" Synthesis of Intrinsically Hydrophilic Dendrons and Dendrimers Containing Metal Binding Moieties at Each Branching Unit Macromolecules 47, 2199-2213 L. Wang, D.J. Kiemle, C.J. Boyle, E.L. Connors, I. Gitsov

Hybrid Linear-Dendritic Macromolecules: From Synthesis to Applications J. Polym. Sci., Part A: Polym. Chem. 46, 5295-5314 (2008) I. Gitsov

Synthesis of Novel Asymmetric Dendritic-Linear-Dendritic Block Copolymers via “Living” Anionic Polymerization of Ethylene Oxide Initiated by Dendritic Macroinitiators J. Polym. Sci., Part A: Polym. Chem. 45, 5136-5148 (2007) I. Gitsov, A, Simonyan, N.G. Vladimirov

Linear-Dendritic Poly(Ester)-block-Poly(ether)-block-Poly(Ester) ABA copolymers Constructed by a Divergent Growth Method Macromolecules 36, 1068-1074 (2003) K.R. Lambrych, I. Gitsov

Synthesis of new hybrid macromolecules with cyclo-dendritic architecture, Chem. Commun. 2000, 269-270 I. Gitsov, P.T. Ivanova

Hydrogels

Preparation and Characterization of Novel Amphiphilic Hydrogels with Covalently Attached Drugs and Fluorescent Markers, Macromolecules 43, 10017-10030 (2010); C. Lin, I. Gitsov

Synthesis and Physical Properties of Reactive Amphiphilic Hydrogels Based on Poly(p-chloromethylstyrene) and Poly(ethylene glycol): Effects of Composition and Molecular Architecture, Macromolecules 43, 3256-3267 (2010); C. Lin, I. Gitsov

Novel Materials for Bioanalytical and Biomedical Applications: Environmental Response and Binding/Release Capabilities of Amphiphilic Hydrogels with Shape-Persistent Dendritic Junctions J. Polym. Sci., Part A: Polym. Chem. 43, 4017-4029 (2005) C. Zhu, C. Hard, C. Lin, I. Gitsov

Novel Functionally Grafted Pseudo Semi-Interpenetrating Networks Constructed by Reactive Linear-Dendritic Copolymers J. Am. Chem. Soc. 125, 11228-11234 (2003) I. Gitsov, C. Zhu

Amphiphilic Hydrogels Constructed by Poly(ethylene Glycol) and Shape-Persistent Dendritic Fragments Macromolecules 35, 8418-8427 (2002) I. Gitsov, C. Zhu

Materials for Biomedical Applications

Synthesis and Hydrolytic Stability of Poly(oxyethylene H-phosphonates) J. Polym. Sci., Part A: Polym. Chem. 46 4130-4139 (2008) I. Gitsov, F.E. Johnson

Immobilization of Aminothiols on Poly(oxyethylene H-phosphonates) and Poly(oxyethylene phosphate)s – an Approach to Polymeric Protective Agents for Radiotherapy of Cancer J. Polym. Sci., Part A: Polym. Chem. 45 1349-1363 (2007) K. Troev, I. Tsatcheva, N. Koseva, R. Georgieva, I. Gitsov

Immobilization of Aminothiols on Poly(oxyalkylene phosphates). Formation of Poly(oxyethylene phosphates)/Cysteamine Complexes and their Radioprotective Efficiency J. Med. Chem. 45 5797-5801 (2002) R. Georgieva, R. Tsevi, K. Kossev, R. Kusheva, M. Balgjiska, R. Petrova, V. Tenchova, I. Gitsov, K. Troev

Dendritic-polymer drug delivery structures characterized by a novel triple detection method Drug Disc. Today 6(2), 108-109 (2001) I. Gitsov, P. Clarke

Materials for Biotechnological Applications

"Green" Synthesis of Unnatural Poly(Amino Acid)s with Zwitterionic Character and pH-Responsive Solution Behavior, Mediated by Linear-Dendritic Laccase Complexes Biomacromolecules 15, 4082-4095 (2014) I. Gitsov, L. Wang, N. Vladimirov, A. Simonyan, D.J. Kiemle, A. Schutz

“Green” Synthesis of Bisphenol Polymers and Copolymers, Mediated by Supramolecular Complexes of Laccase and Linear-Dendritic Block Copolymers, Green Polymer Chemistry: Biocatalysis and materials II, H.N. Cheng, R.A. Gross, Eds., ACS Symposium Series Vol. 1144, American Chemical Society, Washington DC, 2013, pp. 121-139; I. Gitsov, A. Simonyan

Polymer-Assisted Biocatalysis: Unprecedented Enzymatic Oxidation of Fullerene in Aqueous Medium; J. Polym. Sci., Part A: Polym. Chem. 50, 119-126 (2012); I. Gitsov, A. Simonyan, L. Wang, A. Krastanov, S.W. Tanenbaum, D. Kiemle

Green Oxidation of Steroids in Nano-Reactors Assembled from Laccase and Linear-Dendritic Copolymers Polymer Biocatalysis and Biomaterials, H.N. Cheng, R.A. Gross, Eds., ACS Symposium Series Vol. 999, American Chemical Society, Washington DC, 2008, pp. 110-128;  I. Gitsov, A. Simonyan, A. Krastanov, S. Tanenbaum

Enzymatic Nano-reactors for Environmentally Beningn Biotransformations. 1. Formation and Catalytic Activity of Supramolecular Complexes of Laccase and Linear Dendritic Block Copolymers Biomacromolecules 9, 804-811 (2008)

Nondestructive Regioselective Modification of Laccase by Linear-Dendritic Copolymers. Enhanced Oxidation of Benzo-a-Pyrene in Water Polymer Biocatalysis and Biomaterials, H.N. Cheng, R.A. Gross, Eds., ACS Symposium Series Vol. 900, American Chemical Society, Washington DC, 2005, 80-94; I. Gitsov, K. Lambrych, P. Lu, J. Nakas, J. Ryan and S. W. Tanenbaum

Smart Polymer Recycling (with Prof. K. Troev)

Smart Polymer Recycling: Synthesis of Novel Rigid Polyurethanes Using Phosphorus-Containing Oligomers Formed by Controlled Degradation of Microporous Polyurethane Elastomer J. Appl. Polym. Sci. 105, 302-308 (2007) K. Troev, G. Grancharov, V. Mitova, St. Shenkov, A. Topliyska, Ivan Gitsov

Phosphorus-Containing Oligoamides Obtained by a Novel One-Pot Degradation of Polyamide-6 Polym. Degrad. Stab. 91, 778-788 (2006) K. Troev, N. Todorova, V. Mitova, St. Vassileva, I. Gitsov

A Novel Catalyst for the Glycolysis of Poly(ethylene terephthalate) J. Appl. Pol. Sci. 90, 1148-1152 (2003) K. Troev, G. Grancharov, R. Tsevi, I. Gitsov

A Novel Depolymerization Route to Phosphorus-containing Oligocarbonates Polymer 42, 39-42 (2001) K. Troev, R. Tsevi, I. Gitsov

Representative Publications


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