217 Jahn Lab
1 Forestry Dr.
Syracuse, New York 13210
The research efforts in our group are focused on the design, synthesis and evaluation of novel polymers and copolymers with unique architecture, composition and properties that can be used for advanced applications. The synthetic projects involve extensive use of various methods for organic functional group (trans)formation, polycondensation techniques and multiple procedures for controlled or "living" chain-growth polymerization. State-of-the-art methods for isolation, identification and characterization of the macromolecules formed are used including size-exclusion chromatography with multiple detection, FT-IR, UV-Vis, Fluorescence and NMR spectroscopies, mass spectrometry and microscopy. The biological activity and biocompatibility of selected materials are evaluated in collaboration with other research groups and laboratories in USA and Europe. The combination of these methods places our research at the interfaces of organic chemistry, polymer science, biotechnology and molecular medicine.
Our efforts are almost equally divided between the creation of novel macromolecular architectures (linear-dendritic copolymers and hydrogels, star-graft and comb-graft copolymers) and the evaluation of materials formed for novel biomedical applications (polymeric prodrugs, systems for covalent or passive drug binding and sustained delivery) and for new biotechnological applications (formation of unique semi-artificial enzymes through site-specific nano-contacts and no chemical / genetic modification of the proteins).
A leading motif throughout our research is the development and use of “green” and sustainable chemistry practices.
Cross-polarized optical micro-photography of a supermolecule formed in water by self-assembly of amphiphilic linear-dendritic copolymers.
|Self-Assembly of [G-2]-PEG5000-[G-2] in Aqueous Media: Left - unimers below cmc ; Center - onset of self-assembly; Right - supermolecule with dendritic core and linear shell. (For more details see Gitsov et al., J. Polym. Sci., Part A: Polym. Chem. 2000, 38, 2711-2727)|
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Graduate Research Topic
Synthesis And Characterization Of Bone Cement Additives Based On Hydroxyapatite-Grafted Poly(D,L-Lactide).
Hybrid Linear-Dendritic Macromolecules: From Synthesis to Applications J. Polym. Sci., Part A: Polym. Chem. 46, 5295-5314 (2008) I. Gitsov
Synthesis of Novel Asymmetric Dendritic-Linear-Dendritic Block Copolymers via “Living” Anionic Polymerization of Ethylene Oxide Initiated by Dendritic Macroinitiators J. Polym. Sci., Part A: Polym. Chem. 45, 5136-5148 (2007) I. Gitsov, A, Simonyan, N.G. Vladimirov
Linear-Dendritic Poly(Ester)-block-Poly(ether)-block-Poly(Ester) ABA copolymers Constructed by a Divergent Growth Method Macromolecules 36, 1068-1074 (2003) K.R. Lambrych, I. Gitsov
Synthesis of new hybrid macromolecules with cyclo-dendritic architecture, Chem. Commun. 2000, 269-270 I. Gitsov, P.T. Ivanova
Preparation and Characterization of Novel Amphiphilic Hydrogels with Covalently Attached Drugs and Fluorescent Markers, Macromolecules 43, 10017-10030 (2010); C. Lin, I. Gitsov
Synthesis and Physical Properties of Reactive Amphiphilic Hydrogels Based on Poly(p-chloromethylstyrene) and Poly(ethylene glycol): Effects of Composition and Molecular Architecture, Macromolecules 43, 3256-3267 (2010); C. Lin, I. Gitsov
Novel Materials for Bioanalytical and Biomedical Applications: Environmental Response and Binding/Release Capabilities of Amphiphilic Hydrogels with Shape-Persistent Dendritic Junctions J. Polym. Sci., Part A: Polym. Chem. 43, 4017-4029 (2005) C. Zhu, C. Hard, C. Lin, I. Gitsov
Novel Functionally Grafted Pseudo Semi-Interpenetrating Networks Constructed by Reactive Linear-Dendritic Copolymers J. Am. Chem. Soc. 125, 11228-11234 (2003) I. Gitsov, C. Zhu
Amphiphilic Hydrogels Constructed by Poly(ethylene Glycol) and Shape-Persistent Dendritic Fragments Macromolecules 35, 8418-8427 (2002) I. Gitsov, C. Zhu
Synthesis and Hydrolytic Stability of Poly(oxyethylene H-phosphonates) J. Polym. Sci., Part A: Polym. Chem. 46 4130-4139 (2008) I. Gitsov, F.E. Johnson
Immobilization of Aminothiols on Poly(oxyethylene H-phosphonates) and Poly(oxyethylene phosphate)s – an Approach to Polymeric Protective Agents for Radiotherapy of Cancer J. Polym. Sci., Part A: Polym. Chem. 45 1349-1363 (2007) K. Troev, I. Tsatcheva, N. Koseva, R. Georgieva, I. Gitsov
Immobilization of Aminothiols on Poly(oxyalkylene phosphates). Formation of Poly(oxyethylene phosphates)/Cysteamine Complexes and their Radioprotective Efficiency J. Med. Chem. 45 5797-5801 (2002) R. Georgieva, R. Tsevi, K. Kossev, R. Kusheva, M. Balgjiska, R. Petrova, V. Tenchova, I. Gitsov, K. Troev
Dendritic-polymer drug delivery structures characterized by a novel triple detection method Drug Disc. Today 6(2), 108-109 (2001) I. Gitsov, P. Clarke
“Green” Synthesis of Bisphenol Polymers and Copolymers, Mediated by Supramolecular Complexes of Laccase and Linear-Dendritic Block Copolymers, Green Polymer Chemistry: Biocatalysis and materials II, H.N. Cheng, R.A. Gross, Eds., ACS Symposium Series Vol. 1144, American Chemical Society, Washington DC, 2013, pp. 121-139; I. Gitsov, A. Simonyan
Polymer-Assisted Biocatalysis: Unprecedented Enzymatic Oxidation of Fullerene in Aqueous Medium; J. Polym. Sci., Part A: Polym. Chem. 50, 119-126 (2012); I. Gitsov, A. Simonyan, L. Wang, A. Krastanov, S.W. Tanenbaum, D. Kiemle
Green Oxidation of Steroids in Nano-Reactors Assembled from Laccase and Linear-Dendritic Copolymers Polymer Biocatalysis and Biomaterials, H.N. Cheng, R.A. Gross, Eds., ACS Symposium Series Vol. 999, American Chemical Society, Washington DC, 2008, pp. 110-128; I. Gitsov, A. Simonyan, A. Krastanov, S. Tanenbaum
Enzymatic Nano-reactors for Environmentally Beningn Biotransformations. 1. Formation and Catalytic Activity of Supramolecular Complexes of Laccase and Linear Dendritic Block Copolymers Biomacromolecules 9, 804-811 (2008)
Nondestructive Regioselective Modification of Laccase by Linear-Dendritic Copolymers. Enhanced Oxidation of Benzo-a-Pyrene in Water Polymer Biocatalysis and Biomaterials, H.N. Cheng, R.A. Gross, Eds., ACS Symposium Series Vol. 900, American Chemical Society, Washington DC, 2005, 80-94; I. Gitsov, K. Lambrych, P. Lu, J. Nakas, J. Ryan and S. W. Tanenbaum
Smart Polymer Recycling: Synthesis of Novel Rigid Polyurethanes Using Phosphorus-Containing Oligomers Formed by Controlled Degradation of Microporous Polyurethane Elastomer J. Appl. Polym. Sci. 105, 302-308 (2007) K. Troev, G. Grancharov, V. Mitova, St. Shenkov, A. Topliyska, Ivan Gitsov
Phosphorus-Containing Oligoamides Obtained by a Novel One-Pot Degradation of Polyamide-6 Polym. Degrad. Stab. 91, 778-788 (2006) K. Troev, N. Todorova, V. Mitova, St. Vassileva, I. Gitsov
A Novel Catalyst for the Glycolysis of Poly(ethylene terephthalate) J. Appl. Pol. Sci. 90, 1148-1152 (2003) K. Troev, G. Grancharov, R. Tsevi, I. Gitsov
A Novel Depolymerization Route to Phosphorus-containing Oligocarbonates Polymer 42, 39-42 (2001) K. Troev, R. Tsevi, I. Gitsov