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Robert Smith

Robert P. Smith
Assistant Director, N.C. Brown Center for Ultrastructure Studies

213 Baker Lab
1 Forestry Dr.
Syracuse, New York 13210

Phone: (315) 470-6871/470-6637

Email: rpsmith@esf.edu

Overall Statement

Interested in the microscopy and ultrastructure of biological subjects. Familiar with light, fluorescence, immunocytochemistry, electron, atomic force, raman, confocal microscopy of bacteria, viruses, vertebrates, invertebrates, plants, their preparation and interpretation. Electron tomography and 3D reconsctruction of small particles. Current in scientific literature.

Education

BS, 1970 SUNY ESF. MS, 1977 SUNY ESF and Syracuse University: Ultrastructural pathology of Lymantria dispar.

Professional Positions

  • Technical Specialist 1968-1979, SUNY ESF, Entomology Dept
  • 1979-1985 QC Microbiologist, Miller Brewing Co. Fulton, NY & Irwindale, CA
  • 1985 Plant Sanitarian, Miller Brewing Co. Irwindale, CA
  • 1985-1986 Electron Microscopist, Anatomy Dept. SUNY Upstate Medical Center
  • 1986-1994 Director, Electron Microscopy, Surgical Pathology SUNY Upstate Hosp.
  • 1994-2006 Sr. Research Scientist, Wyeth Vaccines Research, Roch. and Pearl River, NY
  • 2006 Electron Microscope Consultant, Wyeth Cardiovascular Research, Radnor, PA

Courses

Histotechnique (ESF), Scanning Electron Microscopy (Upstate Medical School). Labs (ESF): General Entomology, Insects Affecting Wood Products, Insect Physiology, Aquatic Entomology, Insecticide Toxicology

Honors and Awards

Student Council Representative
Graduate Student President
Robin Hood Oak Award, SUNY ESF
Originator and Editor of Graduate Newspaper
Who’s Who in American Colleges and Universities
Two copyrights Ó for inventions R-992 and S-999 granted from SUNY Research Foundation Technology Transfer Office for specialized electron microscope supplies.
Wyeth Research Conference Featured Speaker, 1999 and 2000
Electron Micrograph Exhibitor at the Mudder Museum, Philadelphia, PA
Sponsored by Gordon CryoTEM Conference as the Pharmaceutical Representative 2005
Certified by Wyeth Research as radiation supervisor
Program Director, Microscopy Colloquium Upstate Medical Center, Syracuse, NY.1993.
Sustaining Member Microscopy Society of America and attendee of international meetings 1995-2005. Certified in all Cryo and AFM courses offered by MSA.
Eight-year member of Wyeth’s Community Education Committee.
Wyeth Certificate of Recognition for Outstanding Achievement 2000.
Grants: $7,000 from NYS Health Department for elemental analysis of plants from polluted sites. $48,000 from USFS for propagation of gypsy moth virus. High scorer on McIntyre-Stenis grant proposals. Research Equipment Grants from Wyeth Pharmaceuticals: Freeze-Substitution Device $22,000; Freeze-Fracture Device $40,000; Ion Beam Coater $38,000; Cyroultramicrotome $65,000; Confocal Microscope $225,000; Field Emission Scanning Electron Microscope with Cryo-attachment $485,000; New Design and Construction of Electron Microscope Lab $450,000.
Research: Part of a Wyeth Research team that developed and marketed the RotashieldÒ (rotavirus) and Meningitec Ò (Neisseria meningitidis) vaccines. Developed autoradiographic methods to locate antiarrhythmic drugs in cardiac muscle. Performed plating, negative staining and immunogold technique on these prokaryotic organisms: Alliococcus, Haemophilus, Helicobacter, Streptococcus, Staphylococcus, Moraxella, Norwalk, Rotavirus, Polio, RSV, HIV, HSV, HPV and insect bacculoviruses for fluorescence, TEM and SEM. Developed PrevnarÒ vaccine negative staining methods.

Publications

  • Smith, RP et al 1976. Mass Rearing of Porthetria dispar For In-host Production of Nuclear Polyhedrosis Virus. NY Entomological Society 84:212.
  • Smith, RP et al 1977. Effects of Nuclear Polyhedrosis Virus of Lymantria dispar on an Ectoparasite, an Ultrastructural Study. NY Entomological Society 85:201.
  • Smith, RP 1977. Research, Rearing and Teaching Facility. In: Facilities for Insect Research and Production. USDA Technical Bulletin No.1576: 40-42.
  • Smith, RP and FE Kurczewski 1980. The Gypsy Moth, its Brachonid Parasite and Nuclear Polyhedrosis Virus. Bull. Entomology. De Pologne 50:189-93.
  • Murthy, U. and RP Smith 1990. Mycobacterium avium Penetration of Intestinal Mucosal Barrier via Epithelial ‘M’ Cells in Peyers’ Patches. Immunol. Invest.18: 613.
  • Smith, RP. 1994. Cover micrograph: Negatively Stained Moraxella catarrhalis Producing Membrane Vesicles. Wyeth-Lederle Vaccines and Pediatrics, Scientific Publications 1989-1994.
  • Chen, D. RP Smith et al 1995. Antibodies to the Usp A Outer Membrane Protein of Moraxella catarrhalis Block Bacterial Attachment in vitro and Are Protective in a Murine Pulmonary Challenge Model. American Society of Microbiology p290: E53.
    Chen, D. RP Smith et al 1995. Evaluation of UspA Outer Membrane Protein of M. catarrhalis as a Vaccine Antigen. American Society of Microbiology p290: E53.
  • Conner, ME. RP Smith et al 1996. Virus-like Particles as a Rotavirus Subunit Vaccine. Journal of Infectious Diseases 174: S88-92.
  • Smith, RP. 1996. First Atomic Force Microscope Image of Rotavirus. In: Digital Instruments Brochure: Nanoscope, AFM Applications for the Biological Sciences, Santa Barbara, CA.
  • Fortuna-Nevin, M, RP Smith et al. 1997. (Poster) Evaluation of Meningococcal Lipooligosaccharides as Vaccines Against Group B Neisseria meningitidis. Wyeth Lederle Vaccines Research Meeting, Saratoga Springs, NY.
  • Fiske, M, RP Smith et al 1997. (Poster) Identification and Characterization of a 70Kda Outer Membrane Protein From Helicobacter plyori Using Mouse Monoclonal Antibodies. Wyeth Lederle Vaccines Research Meeting, Saratoga Springs, NY.
  • Jiang, B. RP Smith et al 1997. Rotavirus G1 VLPs Induce Heterotypic Protection in a Murine Model. American Soc. Virol. 16th mtg. Montana State University.
  • Jiang, B. RP Smith et al 1998. Synthesis of Rotavirus-like Particles in Insect Cells. Biotechnology and Bioengineering. 60: 369-74.
  • Madore, HP, RP Smith et al 1999. Biochemical and Immunological Comparison of Virus-like Particles for a Rotavirus Subunit Vaccine. Vaccine 17: 2461-71.
  • Fulginiti, JP, RP Smith et al 1999. (Poster) Identification and Evaluation of Two Outer Membrane Proteins from Helicobacter pylori as Vaccine Candidates. 10th International Workshop Of Campylobacter, Helicobacter and Related Organisms (Sept 12-16 Baltimore, MD).
  • Zagursky, RJ, RP Smith et al 2000. Identification of a Haemophilus influenzae 5’-Nucleotidase Protein. Infection and Immunity 60: 2525-34.
  • Mason, KW, RP Smith et al 2001. Characterization and Evaluation of Hap(s) as a Vaccine Candidate Against Nontypable Haemophilus influenzae. Recent Advances in Otitis Media. Sendai, Japan.
  • Dermody, K, RP Smith et al 2002. (Poster) A Sensitive Method to Enumerate and to Evaluate Antibody Responses to Chlamydia pneumoniae in vitro. Wyeth Vaccines Discovery Research Meeting, Lake George, NY.
  • Zhang, Y, RP Smith et al 2002. Pneumococcal Protective Protein-1 (Ppp-1): A Novel Intranasal Vaccine Candidate of S. pneumoniae. Third International Symposium of Pneumococci and Pneumoccoal Diseases. P112. Anchorage, Alaska.
  • Chakravarti, DN, RP Smith et al 2002. (Poster) Development of Conditions for Proteolytic Digestion of Intact Streptococcus pneumonia to Identify Surface Localized Proteins by Proteomics. Wyeth Vaccines Research Conference, Lake George, NY.
    Smith, RP et al 2003. (Poster) Alliococcus otitis, a possible cause of otitis media, has a capsule. Wyeth Discovery Research Meeting, Lake George, NY.
  • Fiske, M, RP Smith et al 2003. (Poster) The Helicobacter pylori 19.3 kDa ferritin: Purification, Characterization and Evaluation as a Vaccine Candidate. Wyeth Discovery Research Meeting, Lake George, NY.
  • Ooi, P, RP Smith et all 2003. (Poster) Fluorescence Activated Cell Sorting of Prokaryotic and Eukaryotic Cells. Wyeth Discovery Research Meeting, Lake George, NY.
  • Fletcher, LD, RP Smith et al 2004. Vaccine Potential of the Neisseria meningitidis 2086 Lipoprotein. Infection and Immunity 72: 2088-2100.
  • Smith, RP. 2004. (Poster) Imaging in Vaccine Research: Past, Present and Future. Wyeth Vaccines Discovery Research Meeting, Pearl River, NY.
  • Sellman, B, RP Smith et al 2004. (Poster) Staphylococcal Vaccine Project, the Next Generation. Wyeth Vaccines Discovery Research Meeting, Pearl River, NY.
  • Fulginiti, J, RP Smith et al 2004. (Poster) Assessing Gene Expression of Staphylococcus epidermidis in Three Dimensional Human Bronchio-epithelial Tissue-Like Assemblies. Wyeth Vaccines Discovery Research Meeting. Pearl River, NY.
  • Lo, MC, RP Smith et al. 2004. Probing the Interaction of HTI-286 with Tubulin using a Stilbene analogue. Journal of the American Chemical Society. 126: 9898-9899.
  • Green, BA, RP Smith et al. 2005. PppA, Surface Exposed Protein of Streptococcus pneumoniae, Elicits Cross Reactive Antibodies That Reduce Colonization in a Murine Intranasal Immunization Challenge Model. Infection and Immunity 2005. 73(2): 981-989.
  • Hennan, J., RP Smith et al. 2005 ZP123 Prevents Spontaneous Ventricular Arrhythmias and Reduces Infarct Size During Myocardial Ischemia/Reperfusion Injury in Open Chest Dogs. Circulation 112(17, suppl. S): U64.
  • Smith, RP 2005. (Poster) Electron Microscopy in Vaccine Discovery: Integrating Technology to Get Answers. Wyeth Research Retreat, Pearl River, NY.
  • Hennan, J., RP Smith et al. 2006. Rotigaptide (ZP123) Prevents Spontaneous Ventricular Arrhythmias and Reduces Infarct Size During Myocardial Ischemia/Reperfusion Injury in Open-Chest Dogs. J Pharmacol. Exp. Ther. April, 317(1): 236-43.

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