The Bioprocessing Certificate entails 15 credit hours derived from the Paper and Bioprocess Engineering Graduate Program at SUNY-ESF. Participants must earn a grade of B or better for successful completion. Courses are described below.
All participants take the following four courses and choose one of the two synthesis courses.
- Introduction to Industrial Bioprocessing (ERE 796 / 3 credits)
Industrial examples of biotechnology and bioprocessing will be reviewed. Topics include applications of biotechnology and bioprocessing to the food, water and wastewater treatment, industrial biotechnology, biopharmaceutical and biofuel industries. Through case studies of process flow sheets for different products students will develop an understanding of unit operations typically utilized in bioprocessing manufacturing operations.
- Microbiology for Bioprocessing (ERE 501 / 3 credits)
Lectures, conferences, discussions and laboratory. Topics in environmental and resource engineering not covered in established courses. An overview of microbiology, biochemistry, enzyme technology, metabolic pathways and microbial growth kinetics. Discussion of mammalian cell lines, medium formulations and bioreactor design,including batch, fed-batch and continuous.
Topics include general microbiology, molecular engineering, enzymology, enzyme kinetics, metabolic regulation, microbial growth and product formation (with general stoichiometry), media formulation and bioprocess design including batch, fed-batch, and continuous modes, techniques for product recovery and purification, and mammalian cell lines/culture. Laboratory sessions include hands-on experience with a variety of microbiological laboratory techniques, operation of a bench-scale fermentor/bioreactor, and polyhydroxyalkanoate (PHA) biopolymer production, recovery, and characterization. A working knowledge of microbiology is critical for professionals involved in a wide range of industries, including, but not limited to pharmaceuticals, personal care products, food processing, breweries and distilleries, paper and pulp, emerging biorefineries, biotechnology and biomolecules, petroleum and allied products, chemicals and fertilizers, clothing and textiles and public health.
- Bioseparations (ERE 502 / 3 credits)
Lectures, conferences, discussions and laboratory. Topics in environmental and resource engineering not covered in established courses. Topics covered include: cell disruption, centrifugation, chromatographic techniques (gel filtration, affinity, ion exchange), and membrane processes (micro and ultrafiltration, dialysis, reverse osmosis). Crystallization, drying, and a brief discussion of packaging. In addition, preparing water for injection (WFI), viral clearance and aseptic preparation of biologics.
- Bioprocess Engineering (ERE 542 / 3 credits)
Lectures, conferences, discussions and laboratory. Topics in environmental and resource engineering not covered in established courses. An economic analysis of bioprocesses, including equipment, installation and operating cost estimates, and methods for estimating return on investment. Bioprocess flow sheet synthesis, operability, and process simulation will be provided. Optimization techniques will be discussed. Preparation for a bioprocess design project.
Participants choose one of the following two synthesis courses:
- Bioprocess Plant Design (BPE 503 / 3 credits)
This course provides a broad overview of coordinating and balancing the upstream and downstream process systems to balance the cycle times through appropriate selection of a variety of Process Equipment and Process Support functions. Using the various functions needed in a typical Biologics Manufacturing Plant, general concepts of facility design will be developed. Emphasis on specifics to Biologics like GMPs, Automation and Validation, Clean-Dirty Concepts, and, People and Product Flow and Protection will be addressed. Capital Investment and Product Cost and methods for estimating Return on Investment will be covered. Topics covered will cross reference to real life practices in a Biologics Manufacturing Plant.
- Biomass Resources and Emerging Bioenergy Industries (ERE 796 / 3 credits)
As fossil fuel supplies decline and the awareness of the association between the use of fossil fuels and negative environmental impacts increases, the interest in biomass as one of several sources of renewable energy is expanding rapidly. Biomass is currently the largest source of renewable energy in the U.S. and wood is the single largest source of biomass. Biomass for bioenergy, biofuels and bioproducts can also come from agriculture crops and residues, dedicated energy crops, and other waste streams. In addition to the array of different sources of biomass there are various conversion technologies that can be used to produce a variety of forms of energy (e.g heat, electricity, biofuels) and products. This course will provide an overview of the production and conversion of biomass for the production of bioenergy, biofuels and bioproducts and explore how businesses are turning these ideas into viable operations.