Christopher T. NomuraVice President for Research
200 Bray Hall
1 Forestry Drive
Syracuse, NY 13210
- Ph.D. 2001, Biochemistry, Microbiology, and Molecular Biology, The Pennsylvania State University. Postdoctoral Associate, RIKEN Institute, Japan 2001-2006.
Christopher T. Nomura's research interests center on using molecular techniques to improve the supply of precursors for biobased products. Examples include using protein and metabolic engineering techniques to generate recombinant bacterial strains to enhance production of polyhydroxyalkanoate (PHA) biodegradable polymers from renewable resources such as sugars and plant oils. Current and previous studies have used rational design of fatty acid biosynthetic enzymes based on x-ray crystal structures to alter their substrate specificity to provide monomers for PHA biosynthesis. Other research interests include genomic and transcriptomic studies, in vitro evolution for enzyme improvement, microbial physiology, biodegradable polymer production, and polymer characterization studies.
- Zhu, C., Nomura, C.T., Perrotta, J.A., Stipanovic, A.J., and J.P. Nakas. (2012). The effect of nucleating agents on physical properties of poly-3-hydroxybutyrate (PHB) and poly-3-hydroxybutyrate-co-3-hydroxyvalerate (PHB-co-HV) produced by Burkholderia cepacia ATCC 17759. Polym Testing. 31. 579-585.
- Hiroe, A., Tsuge, K., Nomura, C.T., Itaya, M., and T. Tsuge (2012). Rearrangement of phaABC gene order leads to effective production of ultra-high-molecular-weight poly[(R)-3-hydroxybutyrate] in genetically engineered Escherichia coli. Appl Environ Microbiol. 78(9). 3177-3184.
- Tappel, R.C., Wang, Q., and C.T. Nomura (2012). Precise control of repeating unit composition in biodegradable poly(3-hydroxyalkanoate) polymers synthesized in Escherichia coli. J Biosci Bioeng. 114(4), 480-486
- Wang, Q., Tappel, R.C., Zhu, C., and C.T. Nomura (2012). Development of a new strategy for production of medium-chain-length polyhydroyalkanoates (MCL-PHAs) from inexpensive non-fatty acid feedstocks in recombinant Escherichia coli. Appl Environ Microbiol. 78(2). 519-527.
- Mueller, A.P. and C.T. Nomura (2012). Mutations to the active site of 3-ketoacyl-ACP synthase III (FabH) increase polyhydroxyalkanoate biosynthesis in transgenic Escherichia coli. J Biosci Bioeng. 113(3). 300-306.
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