Cohen, S.G.; Elkind, J.L.; Chishti, S.B.; Giner, J.-L.P.; Reese, H.; Cohen, J.B.,
"Effects of Volume and Surface Property in Hydrolysis by Acetylcholinesterase. The
Trimethyl Site", J. Med. Chem.1984, 27,1643-1647.
Giner, J.-L.; Zimmerman, M.P.; Djerassi, C., "Synthesis of (24R,28R)- and (24S,28S)-24,28-Methylene-5-stigmasten-3β-ol
and Biosynthetic Implications of Cyclopropyl Cleavage to 24-Substituted Cholesterols", J. Org. Chem. 1988, 53, 5895-5902.
Hensens, O.D.; Giner, J.-L.; Goldberg, I.H., "Biosynthesis of NCS Chrom A, the Chromophore
of the Antitumor Antibiotic Neocarzinostatin", J. Am. Chem. Soc. 1989, 111,3295-3299.
Giner, J.-L.; Margot, C.; Djerassi, C., "Scope and Regiochemical Control of the Allylpotassium
Reaction in the Synthesis of Sterols with Unsaturated Side Chains", J. Org. Chem. 1989, 54, 2117-2125.
Giner, J.-L.; Margot, C.; Djerassi, C., "Stereospecificity and Regiospecificity of
the Phosphorus Oxychloride Dehydration of Sterol Side Chain Alcohols", J. Org. Chem. 1989, 54, 369-373.
Giner, J.-L.; Djerassi, C., "Use of Sponge Cell-Free Extracts in the Study of Marine
Sterol Biosynthesis", Tetrahedron Lett. 1990, 31, 5421-5424.
Giner, J.-L.; Djerassi, C., "Inhibition and Substrate Specificity of Yeast Δ22 -Desaturase",
Biochem. Biophys. Res. Commun. 1990, 173, 60-66.
Giner, J.-L.; Silva, C.J.; Djerassi, C., "The Missing Step in Sterol Cyclopropyl Biosynthesis:
Enzymatic Desaturation of 24(S)-Ethylcholesterol", J. Am. Chem. Soc. 1990, 112,9626-9627.
Giner, J.-L.; Djerassi, C., "Biosynthesis of 24-Methylene-25-methylcholesterol in
Phaseolus Vulgaris", Phytochemistry1991, 30, 811-814.
Giner, J.-L.; Djerassi, C., "Evidence for a Protonated Cyclopropyl Intermediate in
the Biosynthesis of 24-Propylidenecholesterol", J. Am. Chem. Soc. 1991, 113, 1386-1393.
Giner, J.-L.; Djerassi, C., "Biosynthesis of Dinosterol, Peridinosterol, and Gorgosterol:
Unusual Patterns of Bioalkylation in Dinoflagellate Sterols", J. Org. Chem. 1991, 56, 2357-2363.
Giner, J.-L.; Djerassi, C., "Generation of the Cyclopropane Ring of Sormosterol",
Acta Chem. Scand. 1992, 46, 678-679.
Silva, C.J.; Giner, J.-L.; Djerassi, C., "Enzymatic Desaturation of 24(S)-Methylcholesterol
to 23,24-Methylenecholesterol, Norficisterol, and Norhebesterol. Further Evidence
for a Unified Biosynthesis of Marine Sterols with Unique Side Chains", J. Am. Chem. Soc. 1992, 114, 295-299.
Giner, J.-L.; Djerassi, C., "23-Epidihydrocalysterol: A New Cyclopropane-Containing
Sponge Sterol", Steroids, 1992, 57, 258-261.
Giner, J.-L.; Djerassi, C., "Evidence for Sterol Side Chain Dealkylation in an Alga",
Phytochemistry1992, 31, 3865-3867.
Giner, J.-L., "Biosynthesis of Marine Sterol Side Chains", Chem. Rev. 1993, 93, 1735-1752.
Giner, J.-L.; Rando, R.R., "A Novel Methyltranferase Activity Modifying the Carboxy
Terminal bis(Geranylgeranyl)-Cys-Ala-Cys Structure of Small GTP-Binding Proteins",
Biochemistry1994, 33, 15116-15123.
Giner, J.-L.; Hormann, R.; Arigoni, D. "Multiply Labelled Substrates as Tools for
the Study of an Unusual Biomethylation Reaction", In "Proceedings of the 5th International
Symposium on the Synthesis and Applications of Isotopes and Isotopically Labelled
Compounds 1994, Strasbourg, France", Allen, J. and Voges, R., Eds., John Wiley & Sons, London,1995, pp. 723-726.
Giner, J.-L.; Djerassi, C., "A Reinvestigation of the Biosynthesis of Lanosterol in
Euphorbia lathyris", Phytochemistry1995, 39, 333-335.
Giner, J.-L.; Buzek, P.; Schleyer, P. v. R., "The Mechanism of Cyclopropane-Cyclopropane
Rearrangements in Marine Sterol Biosynthesis: Ab Initio Calculations on Protonated
Ethylcyclopropane", J. Am. Chem. Soc. 1995, 117, 12871-12872.
Marom, M.; Parish, C. A.; Giner, J.-L.; Rando, R.R., "Minimal Structural Requirements
for Diglyceride-Site Directed Activators of Protein Kinase C", Tetrahedron1997, 29, 10041-10050.
Giner, J.-L.; Boyer, G.L., "Sterols of the Brown Tide Alga Aureococcus anophagefferens",
Phytochemistry1998, 48, 475-477.
Giner, J.L., "New and Efficient Synthetic Routes to 1-Deoxy-D-xylulose", Tetrahedron Lett.1998, 39, 2479-2482.
Giner, J.-L.; Jaun, B.; Arigoni, D., "Biosynthesis of Isoprenoids in Escherichia coli:
The Fate of the 3-H and 4-H Atoms of 1-Deoxy-D-xylulose", J. Chem. Soc., Chem. Commun. 1998, 1857-1858.
Giner, J.-L.; Jaun, B., "Biosynthesis of Isoprenoids in Escherichia coli: Retention
of the Methyl H-Atoms of 1-Deoxy-D-Xylulose", Tetrahedron Lett.1998, 39, 8021-8022.
Arigoni, D., Giner, J.-L.; Sagner, S., Wungsintaweekul, J., Zenk, M.H., Kis, K., Bacher,
A., Eisenreich, W., "Stereochemical Course of the Reduction Step in the Formation
of 2-C-Methyl-Erythritol From the Terpene Precursor 1-Deoxyxylulose in Higher Plants",
J. Chem. Soc., Chem. Commun. 1999, 1127-1128.
Giner, J.-L.; Gunasekera, S.P.; Pomponi, S.A., "Sterols from the Marine Sponge Petrosia
Weinbergii: Implications for the Absolute Configuration of the Antiviral Weinbersterols
and Orthoesterols", Steroids1999, 64, 820-824.
Giner, J.-L.; Berkowitz, J.D.; Andersson, T., "Nonpolar Components of the Latex of
Euphorbia peplus", J. Nat. Prod.2000, 63, 267-269.
Lovato, M.A.; Hart, E.A.; Segura, M.J.R.; Giner, J.-L.; Matsuda, S.P.T., "Functional
Cloning of an Arabidopsis thaliana cDNA Encoding Cyclopropyl Isomerase", J. Biol. Chem. 2000, 275, 13394-13397.
Giner, J.-L.; Li, X., "Stereospecific Synthesis of 24-Propylcholesterol Isolated from
the Texas Brown Tide", Tetrahedron2000, 56, 9575-9580.
Giner, J.-L.; Li, X.; Boyer, G.L., "Sterol Composition of Aureoumbra lagunensis, the
Texas Brown Tide Alga", Phytochemistry2001, 57, 787-789.
Giner, J.-L.; Beach, D.H.; Parish, E.J.; Jayasimhulu, K.; Kaneshiro, E.S., "Definitive
structural identities of 42 sterol components in Pneumocystis carinii", J. Eukaryot. Microbiol. 2001, 48, 142S-143S.
Kaneshiro, E.S.; Rosenfeld, J.A.; Basselin, M.; Bradshaw, S.; Stringer, J.R.; Smulian,
A.G.; Giner, J.-L., "Pneumocystis carinii erg6 gene: sequencing and expression of
recombinant SAM:sterol methyltransferase in heterologous systems", J. Eukaryot. Microbiol. 2001, 48, 144S-146S.
Giner, J.-L.; Zhao, H.; Beach, D.H.; Parish, E.J.; Jayasimhulu, K.; Kaneshiro, E.S.,
"Comprehensive and definitive structural identities of Pneumocystis carinii sterols",
J. Lipid Res.2002, 43, 1114-1124.
Kaneshiro, E.S.; Rosenfeld, J.A.; Basselin-Eiweida, M.; Bradshaw, S.; Stringer, J.R.;
Smulian, A.G.; Giner, J.-L., "The Pneumocystis carinii drug target S-adenosyl-L-methionine:sterol
C-24 methyl transferase has a unique substrate preference", Mol. Microbiol.2002, 44, 989-999.
Giner, J.-L.; Kiemle, D.; Zuniga, D.J., "Analysis of 2-Deuterated Isopentenyl Alcohols
by 1H-NMR of Chiral Esters", Tetrahedron Lett.2002, 43, 1175-1177.
Giner, J.-L.; Faraldos, J.A., "A Biomimetic Approach to the Synthesis of an Antiviral
Marine Steroidal Orthoester", J. Org. Chem. 2002, 67, 2717-2720.
Giner, J.-L.; Faraldos, J.A., "A Biomimetic Synthesis of Petuniasterone D via the
Epoxy Ester - Orthoester Rearrangement", J. Org. Chem.2002, 67, 4659-4666.
Giner, J.-L.; William V. Ferris, J., "Synthesis of 2-C-methyl-D-erythritol 2,4-cyclopyrophosphate",
Org. Lett.2002, 4, 1225-1226
Giner, J.-L.; William V. Ferris, J.; Mullins, J.J., "Synthesis of 2-Methyl-D-erythritol
via Epoxy Ester-Orthoester Rearrangement", J. Org. Chem.2002, 67, 4856-4859.
Giner, J.-L.; Arigoni, D., "Enantiomerically Enriched [2-2H]-Isopentenyl Alcohol from
(E)-2-Methyl-2-butene-1,4-diol by an Asymmetric Retro-Ene Reaction", Chem. Commun.2002, 1388-1389.
Giner, J.-L., "A Convenient Synthesis of (E)-4-Hydroxy-3-methyl-2-butenyl Pyrophosphate
and its [4-13C]-Labeled Form", Tetrahedron Lett.2002, 43, 5457-5459.
Giner, J.-L.; Faraldo, J.A.; Boyer, G.L., "Unique Sterols of the Toxic Dinoflagellate
Gymnodinium breve (Dinophyceae): A Defensive Function for Unusual Marine Sterols?",
J. Phycol.2003, 39, 315-319.
Crowell, D.N.; Packard, C.E.; Pierson, C.A.; Jose-Luis, G.; Downes, B.P.; Chary, S.N.,
"Identification of an Allele of CLA1 Associated with Variegation in Arabidopsis thaliana",
Physiol. Plant.2003, 118, 29-37.
Giner, J.-L.; Faraldos, J.A., "Facile Orthoester Formation in a Model Compound of
the Taxol Oxetane: Are Biologically Active Epoxy Esters, Orthoesters and Oxetanyl
Esters Latent Electrophiles?", Helv. Chim. Acta2003, 86, 3613-3622.
Giner, J.-L.; Li, X.; Mullins, J.J., "Mechanistic Studies of the Biomimetic Epoxy
Ester - Orthoester and Orthoester - Cyclic Ether Rearrangements", J. Org. Chem.2003, 68, 10079-10086.
Zhao, H.; Giner, J.-L.; Kaneshiro, E.S., "Definitive structural identities of Pneumocystis
jirovecii sterols", J. Eukaryot. Microbiol. 2003, 50, 680.
Giner, J.-L.; Zhao, H.; Amit, Z.; Kaneshiro, E. S.,Sterol composition of Pneumocystis
jirovecii with blocked 14a-demethylase activity, J. Eukaryot. Microbiol.2004, 51, 634-643.
Giner, J.-L.; Zhao, H.,Detailed Sterol Compositions of Two Pathogenic Rust Fungi,
Lipids2004, 39, 763-767.
Giner, J.-L., DMOBO: An Improvement on the OBO Orthoester Protecting Group, Org. Lett. 2005, 7, 499-501.
Giner, J.-L.,Tetrahydropyran Formation by Rearrangement of an Epoxy Ester: A Model
for the Biosynthesis of Marine Polyether Toxins, J. Org. Chem. 2005, 70, 721-724.
Giner, J.-L.; Rocchetti, S.; Neunlist, S.; Rohmer, M.; Arigoni, D.,"Detection of 1,2-hydride
shifts in the formation of euph-7-ene by the squalene-tetrahymanol cyclase of Tetrahymena
pyriformis", Chem. Commun. 2005, 3089-3091.
Müller-Schwarze, D.; Giner, J., Cottontails and Gopherweed: Anti-Feeding Compounds
from a Spurge. In Chemical Signals in Vertebrates, Mason, R. T.; LeMaster, M. P.;
Müller-Schwarze, D., Eds. Springer: New York, NY, 2005; Vol. 10, pp 409-416.
Giner, J.-L.; Zhao, H., "A convenient method for the preparation of 4,7-steroidal
3-ketones and 5,7-sterols", Polish J. Chem.2006, 80, 605-609.
Giner, J.-L.; Kehbein, K. A.; Cook, J. A.; Smith, M. C.; Vlahos, C. J.; Badwey, J.
A., "Synthesis of fluorescent derivatives of wortmannin and demethoxyviridin as probes
for phosphatidylinositol 3-kinase", Bioorg. Med. Chem. Lett.2006, 16, 2518-2521.
Jayasimhulu, K.; Hunt, S. M.; Kaneshiro, E. S.; Watanabe, Y.; Giner, J.-L.,"Detection
and Identification of Bacteriovorax stolpii UKi2 Sphingophosphonolipid Molecular Species",
J. Am. Soc. Mass Spectrom. 2007, 18, 394-403.
Giner, J.-L.,"Marine Natural Products”. Topics in Heterocyclic Chemistry, 05 edited
by Hiromasa Kiyota", J. Am. Chem. Soc.2007, 129, 4854-4855.
Puan, K.-J.; Jin, C.; Wang, H.; Sarikonda, G.; Raker Amy, M.; Lee Hoi, K.; Samuelson
Megan, I.; Marker-Hermann, E.; Pasa-Tolic, L.; Nieves, E.; Giner, J.-L.; Kuzuyama,
T.; Morita Craig, T.,"Preferential recognition of a microbial metabolite by human
Vγ2Vδ2 T cells", Int. Immunol.2007, 19, 657-673.
Kutrzeba, L.; Dayan, F. E.; Howell, J. L.; Feng, J.; Giner, J.-L.; Zjawiony, J. K.,"Biosynthesis
of salvinorin A proceeds via the deoxyxylulose phosphate pathway", Phytochemistry2007, 68, 1872-1881.
Giner, J.-L.; Zhao, H.; Tomas, C.," Sterols and Fatty Acids of Three Harmful Algae
Previously Assigned as Chattonella", Phytochemistry2008, 69, 2167-2171.
Puan, K. J.; Low, J. S. H.; Tan, T. W. K.; Wee, J. T. S.; Tan, E. H.; Fong, K. W.;
Chua, E. T.; Jin, C.; Giner, J.-L.; Morita, C. T.; Goh, C. H. K.; Hui, K. M.,"Phenotypic
and functional alterations of Vγ2Vδ2 T cell subsets in patients with active nasopharyngeal
carcinoma", Cancer Immunol. Immunother.2009, 58, 1095-1107.
Faraldos, J. A.; Giner, J.-L.; Smith, D. H.; Wilson, M.; Ronhovde, K.; Wilson, E.;
Clevette, D.; Holmes, A. E.; Rouhier, K.,"Enzymatic Resolution of 1-Phenylethanol
and Formation of a Diastereomer: An Undergraduate 1H NMR Experiment To Introduce Chiral
Chemistry", J. Chem. Educ.2011, 88, 334-336.
Wang, H.; Sarikonda, G.; Puan, K.-J.; Tanaka, Y.; Feng, J.; Giner, J.-L.; Cao, R.;
Mönkkönen, J.; Oldfield, E.; Morita, C. T.,"Indirect Stimulation of Human Vγ2Vδ2 T
Cells Through Alterations in Isoprenoid Metabolism", J. Immunol.2011, 187, 5099-5113.
Giner, J.-L.; Wang, H.; Morita, C. T.,"Synthesis and immunological evaluation of the
4-b-glucoside of HMBPP", Bioorg. Med. Chem. Letters2012, 22, 811-813.
Hong, Y. J.; Giner, J.-L.; Tantillo, D. J.,"Triple Shifts and Thioether Assistance
in Rearrangements Associated with an Unusual Biomethylation of the Sterol Side Chain",
J. Org. Chem. 2013, 78, 935–941.
Sallans, L.; Giner, J.-L.; Kiemle, D. J.; Custer, J. E.; Kaneshiro, E. S.,"Structural
identities of four glycosylated lipids in the oral bacterium Streptococcus mutans
UA159", Biochim. Biophys. Acta2013, 1831, 1239-1249.
Grabenstatter, J.; Méhay, S.; McIntyre-Wressnig, A.; Giner, J.-L.; Edgcomb, V. P.;
Beaudoin, D. J.; Bernhard, J. M.; Summons, R. E.,"Identification of 24-n-propylidenecholesterol
in a member of the Foraminifera", Org. Geochem. 2013, 63, 145-151.
Faraldos, J. A.; Coates, R. M.; Giner, J.-L.,"Alternative Synthesis of the Colorado
Potato Beetle Pheromone", J. Org. Chem.2013, 78, 10548-10554.
Giner, J.-L.; Joseph, R.; Berry, D.; Ceballos, H.; Wikfors, G. H.; Hassett, R. P.,"Diving
Deeper with Marine Sterols", Chem. Listy2014, 108, 1092.
Hong, Y. J.; Giner, J.-L.; Tantillo, D. J.,"Bicyclobutonium ions in biosynthesis -
Interconversion of cyclopropyl-containing sterols from orchids", J. Am. Chem. Soc.2015, 137, 2085-2088.
Kaneshiro, E. S.; Johnston, L. Q.; Nkinin, S. W.; Romero, B. I.; Giner, J.-L.,"Sterols
of Saccharomyces cerevisiae erg6 Knockout Mutant Expressing the Pneumocystis carinii
S-Adenosylmethionine:Sterol C-24 Methyltransferase (SAM:SMT)", J. Eukaryotic Microbiol.2015, 62, 298-306.
Giner, J.-L.; Schroeder, T. N.,"Polygonifoliol, a New Tirucallane Triterpene from
the Latex of the Seaside Sandmat Euphorbia polygonifolia", Chem. Biodivers.2015, 12, 1126-1129.
Giner, J.-L.; Zhao, H.; Dixon, M. S.; Wikfors, G. H.,"Bioconversion of 13C-labeled
microalgal phytosterols to cholesterol by the Northern Bay scallop, Argopecten irradians
irradians", Comp. Biochem. Physiol., Part B: Biochem. Mol. Biol.2016, 192, 1-8.
Giner, J.-L.; Ceballos, H.; Tang, Y.-Z.; Gobler, C. J.," Sterols and Fatty Acids of
the Harmful Dinoflagellate Cochlodinium polykrikoides", Chem. Biodivers.2016, 13, 249-252.
Giner, J.-L.; Feng, J.; Kiemle, D. J., "NMR Tube Degradation Method for Sugar Analysis
of Glycosides", J. Nat. Prod.2016, 79, 2413-2417.
Sasse, J.; Schlegel, M.; Borghi, L.; Ullrich, F.; Lee, M.; Liu, G.-W.; Giner, J.-L.;
Kayser, O.; Bigler, L.; Martinoia, E.; Kretzschmar, T.,"Petunia hybrida PDR2 is involved
in herbivore defense by controlling steroidal contents in trichomes ", Plant, Cell Environ. 2016, 39, 2725–2739.
Banta, A. B.; Wei, J. H.; Gill, C. C. C.; Giner, J.-L.; Welander, P. V.,"Synthesis
of novel arborane triterpenols by a bacterial oxidosqualene cyclase", Proc. Natl. Acad. Sci. U. S. A.2017, 114, 245–250.
Giner, J.-L.; Feng, J.,"Stereochemical investigations of the Tetrahymena cyclase,
a model system for euphane/tirucallane biosynthesis", Org. Biomol. Chem. 2017, 15, 2823 -2830.
Ciulla, D.; Jorgensen, M.; Giner, J.-L.; Callahan, B.,"Rescue of a general base mutant
in hedgehog protein cholesterolysis using a hyper-nucleophilic substrate", J. Am. Chem. Soc.2017, 140, 916-918.
Lee, A. K.; Banta, A. B.; Wei, J. H.; Kiemle, D. K.; Feng, J.; Giner, J.-L.; Welander,
P. V.,"C-4 sterol demethylation enzymes distinguish bacterial and eukaryotic sterol
synthesis", Proc. Natl. Acad. Sci. U. S. A. 2018, 115, 5884-5889.
Ciulla, D. A.; Wagner, A. G.; Liu, X.; Cooper, C. L.; Jorgensen, M. T.; Wang, C.;
Goyal, P.; Banavali, N. K.; Pezzullo, J. L.; Giner, J.-L.; Callahan, B.,"Sterol A-ring
plasticity in hedgehog protein cholesterolysis supports a primitive substrate selectivity
mechanism", ChemComm2019, 54, 1829-1832.
Giner, J.-L.,"Batatasenol, a Major Triterpenol from Sweet Potato Skins", Chem. Biodivers.2019, 16, e1800439.
Zhang, X.; Xu, Z.; Moumin, D. S.; Ciulla, D. A.; Owen, T. S.; Mancusi, R. A.; Giner,
J.-L.; Wang, C.; Callahan, B. P., “Protein-nucleic acid conjugation with sterol linkers
using hedgehog autoprocessing”, Bioconjugate Chem.2019, 30, 2799-2804.
Zhao, J.; Ciulla, D. A.; Xie, J.; Castillo, D. A.; Wagner, A.; Zwarycz, A. S.; Lin,
Z.; Beadle, S.; Giner, J.-L.; Li, Z.; Li, H.; Banavali N.; Callahan, B. P.; Wang,
C., “General Base Swap Preserves Activity and Expands Substrate Tolerance in Hedgehog
Autoprocessing” J. Am. Chem. Soc. 2019, 141, 18380-18384.
Smith, C. J.; Wagner, A. G.; Stagnitta, R. T.; Xu, Z.; Pezzullo,J. L.; Giner, J.-G.;
Xie, J.; Covey, D. F.; Wang, C. Callahan, B. P., “Subverting Hedgehog Protein Autoprocessing
by Chemical Induction of Paracatalysis”, Biochemistry2020, 59, 736−741.
Wagner, A.G.; Stagnitta, R.T.; Xu, Z.; Pezzullo, J.L.; Kandel, N.; Giner, J.-L.; Covey,
D.F.; Wang, C.; Callahan, B. P. “Nanomolar, Noncovalent Antagonism of Hedgehog Cholesterolysis:
Exception to the "Irreversibility Rule" for Protein Autoprocessing Inhibition” Biochemistry2022, 61, 1022-1028.
Ciulla, D. A.; Dranchak, P.; Pezzullo, J. L.; Mancusi, R. A.; Psaras, A. M.; Rai,
G.; Giner, J.-L.; Inglese, J.; Callahan, B. P. “A cell-based bioluminescence reporter
assay of human Sonic Hedgehog protein autoprocessing to identify inhibitors and activators”
J. Biol. Chem.2022, 298, 102705.
Ciulla, D. A.; Xu, Z.; Pezzullo, J. L.; Dranchak, P.; Wang, C.; Giner, J.-L.; Inglese,
J.; Callahan, B. P. “Paracatalytic induction: Subverting specificity in hedgehog protein
autoprocessing with small molecules” Methods Enzymol.2023, 685, 1-41.
Brown, M. O.; Olagunju, B. O.; Giner, J.-L.; Welander, P. V., "Sterol methyltransferases
in uncultured bacteria complicate eukaryotic biomarker interpretations", Nat. Commun.2023, 14, 1859.